All licensed COVID-19 antibody treatments become ineffective over time as new mutants emerge. We isolated antibodies from an individual who recovered from SARS-1 and received the COVID vaccine, that work against all COVID-related viruses including the latest Omicron variants. These broad-targeting antibodies could make future-proof therapeutics to counter the continual evolution of coronaviruses.

The world population is aging. In our recent study, we identified that levels of an amino acid called taurine decline during aging. When we used taurine supplementation to reverse this decline, it improved healthspan in worms, mice and monkeys, and lifespan in worms and mice. Thus, taurine deficiency could be a driver of aging and taurine supplementation a potential anti-aging intervention.

It is widely known that psychological stress influences many aspects of our health. This is particularly true in the case of inflammatory bowel disease (IBD), a widespread disease of the gut. We found that psychological stress leads to inflammation of the gut by changing the gut-residing nervous system, which may inform therapeutic approaches in the future.

Nature has always been an interesting source of chemical diversity for the search of molecules of therapeutic interest. Here we showed how large plant extract libraries can be transformed into a chemical library. This library could then be efficiently used to isolate molecules of unreported bioactivity to advance our knowledge on disease treatments.

Patients with a diagnosis of breast cancer or lymphoma who received chemotherapy treatment might be at risk of long-term side effects. We evaluated the association between a type of chemotherapy, called anthracyclines, and the risk of developing heart failure in patients with cancer. In this study, patients treated with anthracycline were more likely to have heart failure compared to controls.